Botulinum toxin is a neurotoxin protein produced by the bacterium Clostridium botulinum. Primary botulinum toxin is used to treat a number of ophthalmology and neurology disorders There are 8 types botulinum toxin named A, B, C1, C2, D, E, F, G. Botulinum toxin A type is one the most reactive toxins and since 2002 is officially FDA approved for cosmetic use. Temporary and reversible flaccid paralysis is seen because bolutinum toxin prevents the release of neurotransmitter acetylcholine from axon endings at the neuromuscular junction. Thus blocks neuromuscular impuls and causes muscle paralysis. Gradual recovery of axon endings rebuilds neuromuscular junction and botulinum toxin effect is waning. Face muscles partial relaxation provides reduction of involuntary facial expressions and thus smoothes overlying wrinkles, fine lines.
After cleansing the area to be treated and applying numbing medicine on the skin, a series of microinjections are performed at certain points of facial muscles. Smoothing of wrinkles is usually visible 3-5 days after injection and lasts individually for an average of 12-16 weeks. Mandatory aftercare includes 4 hours upright head position. Avoid sports, sauna next few hours following the procedure in order to minimize excessive sweating, muscles contractions.
Bolutinum toxin is administrated in toxin units. Administration is higher in men because of men advanced mimic muscles and depends on individual wrinkles number and depth. The most indicated are patients aged from 35 to 55 years with “dynamic wrinkles” (visible in grimace and disappearing when relaxing) and with retained skin elasticity. Procedure duration is 15-20 minutes and there is an opportunity for quick return to usual activities.
Botulinum toxin is appropriate to smooth “frown lines”, crow’s feet, horizontal forehead lines, bunny lines (wrinkles at the nose basis), for toxin eyebrows lifting, “chin cellulite”, gummy smile, masseteric muscles hypertrophy. Migraine, excessive sweating of palms, steps, arms are the other indications.
Potential side effects are reversible and include headache, dry mouth, bruising in injection points, droopy eyelid, asymmetric smile. You shouldn’t use botulinum toxin if you have disease that affects your muscles, nerves, if you are allergic to toxin, if you are pregnant or breastfeeding woman, if you have skin infection or skin diseases, if you have anticoagulant intake, if you have asthma.
Proper dosage and appropriate patient make botulinum toxin administration a safe and effective procedure. Toxin duration is individual (3-4 months) and subsequent application extends duration and the toxin effect is augmented. It is important to postpone the next toxin procedure at least 3 months so that no toxin antibodies are formed. Static wrinkles (wrinkles seen in relaxed face) are smoothed, but not disappear completely after toxin procedure. Subsequent superficial filler pulling out of remaining parts of these wrinkles is effective solution.
|1.||Botulinum neurotoxin 1 unit||11|
|2.||Excessive perspiration treatment one area ( palms, soles, arms)||600|
|3.||Migraine botulinum neurotoxin treatment||400|